Weekend trips from St. Louis

  1. Madison / Indianapolis
  2. Chattanooga / Memphis
  3. Nashville / Little Rock
  4. Cincinnati / Louisville
  5. Lexington / Birmingham

For any of these trips, you could visit just the first or second destination if you want to do less driving and spend more time in the area.

The longest trip is about 24 hours of total driving, so you may want to plan to do this over a long weekend.


Trip idea #1: St. Louis → Madison → Indianapolis → St. Louis


St. Louis to Madison
leave St. Louis on Friday
53 minutes → Old 66
1 hour → Springfield
1 hour → Bloomington
1 hour → Streator
2 hours → Rockford
1 hour → Whitewater
51 minutes → Madison (stay Friday night)
view all routes
8 hours of driving

Madison to Indianapolis
leave Madison on Saturday
1.5 hours → Rockford
1.5 hours → Arlington Heights
1 hour → Gary
48 minutes → Wheatfield
1 hour → Triple XXX Family Restaurant
1.5 hours → Indianapolis (stay Saturday night)
view all routes
7.5 hours of driving

Indianapolis to St. Louis
leave Indianapolis on Sunday
1.5 hours → Gray Brothers Cafeteria
42 minutes → Terre Haute
56 minutes → Westfield
46 minutes → Altamont
57 minutes → Greenville
28 minutes → St. Louis (back home)
view all routes
5 hours of driving

Total driving time for this trip is about 20.5 hours of driving.


Trip idea #2: St. Louis → Chattanooga → Memphis → St. Louis


St. Louis to Chattanooga
leave St. Louis on Friday
59 minutes → Nashville
2 hours → Paducah
1.5 hours → Clarksville
52 minutes → Nashville
1 hour → Manchester
1 hour → Chattanooga (stay Friday night)
view all routes
8 hours of driving

Chattanooga to Memphis
leave Chattanooga on Saturday
47 minutes → Monteagle
1.5 hours → Franklin
1.5 hours → Hurricane Mills
54 minutes → Lexington
1.5 hours → Germantown
28 minutes → Memphis (stay Saturday night)
view all routes
6.5 hours of driving

Memphis to St. Louis
leave Memphis on Sunday
1.5 hours → Turrell
52 minutes → Hayti
1 hour → Sikeston
49 minutes → Sedgewickville
1 hour → Sainte Genevieve
30 minutes → St. Louis (back home)
view all routes
6 hours of driving

Total driving time for this trip is about 20.5 hours of driving.


Trip idea #3: St. Louis → Nashville → Little Rock → St. Louis


St. Louis to Nashville
leave St. Louis on Friday
59 minutes → Nashville
47 minutes → Burton's Cafe
1 hour → Shawnee National Forest
44 minutes → Paducah
1.5 hours → Hopkinsville
1 hour → Nashville (stay Friday night)
view all routes
6 hours of driving

Nashville to Little Rock
leave Nashville on Saturday
48 minutes → Dickson
1.5 hours → Jackson
1.5 hours → Memphis
49 minutes → Forrest City
1 hour → Lonoke
29 minutes → Little Rock (stay Saturday night)
view all routes
6 hours of driving

Little Rock to St. Louis
leave Little Rock on Sunday
49 minutes → Searcy
59 minutes → Mark Martin Ford
1 hour → Weiner
1.5 hours → Pocahontas
1.5 hours → Wappapello
1 hour → Bonne Terre
54 minutes → St. Louis (back home)
view all routes
7.5 hours of driving

Total driving time for this trip is about 20 hours of driving.


Trip idea #4: St. Louis → Cincinnati → Louisville → St. Louis


St. Louis to Cincinnati
leave St. Louis on Friday
53 minutes → Old 66
1 hour → Altamont
1.5 hours → Terre Haute
1.5 hours → Indianapolis
2 hours → Creation Museum
25 minutes → Cincinnati (stay Friday night)
view all routes
7 hours of driving

Cincinnati to Louisville
leave Cincinnati on Saturday
19 minutes → Fort Mitchell
21 minutes → Walton
27 minutes → Sparta
22 minutes → Carrollton
30 minutes → Lake Jericho Recreational Area
29 minutes → Courtyard Louisville Northeast
21 minutes → Louisville (stay Saturday night)
view all routes
3 hours of driving

Louisville to St. Louis
leave Louisville on Sunday
1 hour → Corydon
1 hour → Jasper
1.5 hours → Evansville
36 minutes → Mount Vernon
59 minutes → Nashville
31 minutes → St. Louis (back home)
view all routes
6 hours of driving

Total driving time for this trip is about 16 hours of driving.


Trip idea #5: St. Louis → Lexington → Birmingham → St. Louis


St. Louis to Lexington
leave St. Louis on Friday
59 minutes → Nashville
2 hours → Evansville
1 hour → Jasper
1 hour → Corydon
1.5 hours → Frankfort
43 minutes → Lexington (stay Friday night)
view all routes
7.5 hours of driving

Lexington to Birmingham
leave Lexington on Saturday
1 hour → Bardstown
1.5 hours → Mammoth Cave National Park
1.5 hours → Springfield
1.5 hours → Cornersville
57 minutes → Decatur
1.5 hours → Birmingham (stay Saturday night)
view all routes
7.5 hours of driving

Birmingham to St. Louis
leave Birmingham on Sunday
2 hours → Fairfield Inn by Marriott Nashville at Opryland
2 hours → Nashville
1.5 hours → Paducah
1 hour → Mount Vernon
2 hours → St. Louis (back home)
view all routes
9 hours of driving

Total driving time for this trip is about 24 hours of driving.



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Discover weekend getaways from St. Louis and explore places that are easily drivable for a short 3-day trip or a longer weekend if there's a holiday or you can get time off. Once you've picked a destination, you can search for alternate routes that might have more interesting stops along the way. If you're looking for all of the possible destinations, try searching for a radius of 50 miles from St. Louis up to 200 miles from St. Louis or anything in between. If you don't have enough time for a long weekend, try searching for day trips from St. Louis, or you can make St. Louis your destination instead. If you have more time, you can plan a drive from St. Louis to Illinois.