Top 6 trips from St. Louis to Memphis

St. Louis to Memphis
starting from St. Louis
33 minutes → Pevely
42 minutes → Sainte Genevieve
1 hour → Cape Girardeau
2 hours → Sikeston
1.5 hours → Blytheville
1 hour → Memphis
5.5 hours of driving
St. Louis to Memphis via Sikeston
starting from St. Louis
2 hours → Sikeston
2 hours → Keiser
52 minutes → Memphis



5 hours of driving
St. Louis to Memphis via Sikeston
starting from St. Louis
33 minutes → Pevely
2 hours → Sikeston
2 hours → Keiser
52 minutes → Memphis


5.5 hours of driving
St. Louis to Memphis via Dyersburg
starting from St. Louis
42 minutes → Sainte Genevieve
1 hour → Cape Girardeau
2 hours → Dyersburg
1.5 hours → Memphis


5.5 hours of driving
St. Louis to Memphis via Dyersburg
starting from St. Louis
33 minutes → Pevely
42 minutes → Sainte Genevieve
1 hour → Cape Girardeau
2 hours → Dyersburg
1.5 hours → Memphis

5.5 hours of driving
St. Louis to Memphis via Little Rock
starting from St. Louis
33 minutes → Pevely
2 hours → Poplar Bluff
1 hour → Pocahontas
2 hours → Little Rock
2 hours → Memphis

8 hours of driving

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Explore alternate routes from St. Louis to Memphis, or you can get reverse directions from Memphis to St. Louis. Don't forget to factor in the weather. You can check the road conditions from St. Louis to Memphis. Check out other stops like Sikeston, Dyersburg, or Little Rock. Try starting your trip from Cahokia, Caseyville, East Saint Louis, Pontoon Beach, Florissant, Hazelwood, Clayton (Missouri), Granite City, or Brentwood (Missouri). You can also change your destination to West Memphis, Southaven (Mississippi), or Marion (Arkansas).