Top 6 trips from St. Louis to Louisville

St. Louis to Louisville
starting from St. Louis
25 minutes → Shiloh
59 minutes → Nashville
1 hour → Mount Vernon
1 hour → Grayville
47 minutes → Evansville
1 hour → Jasper
1.5 hours → Louisville
6.5 hours of driving
East Saint Louis to Louisville
starting from East Saint Louis
1 hour → Mount Vernon
1 hour → Grayville
47 minutes → Evansville
50 minutes → Dale
1 hour → Corydon
31 minutes → Louisville


5.5 hours of driving
East Saint Louis to New Albany
starting from East Saint Louis
59 minutes → Nashville
1 hour → Mount Vernon
46 minutes → Fairfield
47 minutes → Evansville
1 hour → Jasper
1 hour → Corydon
31 minutes → New Albany
6.5 hours of driving
St. Louis to Louisville via Eddyville
starting from St. Louis
59 minutes → Nashville
2.5 hours → Eddyville
2.5 hours → Elizabethtown
48 minutes → Louisville



7 hours of driving
St. Louis to Louisville via Eddyville
starting from St. Louis
59 minutes → Nashville
2.5 hours → Eddyville
2.5 hours → Elizabethtown
48 minutes → Louisville



7 hours of driving
St. Louis to Louisville via Metropolis
starting from St. Louis
59 minutes → Nashville
2 hours → Metropolis
2.5 hours → Falls of Rough
2.5 hours → Elizabethtown
48 minutes → Louisville


7 hours of driving

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Explore alternate routes from St. Louis to Louisville, or you can get reverse directions from Louisville to St. Louis. Don't forget to factor in the weather. You can check the road conditions from St. Louis to Louisville. Check out other stops like Eddyville or Metropolis. Try starting your trip from East Saint Louis, Clayton (Missouri), Cahokia, Fairmont City, or Richmond Heights. You can also change your destination to New Albany (Indiana), Jeffersonville (Indiana), or Clarksville (Indiana).