Explore alternate routes from
St. Louis to
Columbus, or you can get reverse directions from
Columbus to St. Louis.
Don't forget to factor in the weather. You can check the
road conditions from St. Louis to Columbus. Check out other stops like
Cincinnati,
Louisville,
Chicago, or
Branson. Try starting your trip from
Collinsville (Illinois),
Alton,
Cahokia,
Caseyville,
East Saint Louis,
Edwardsville,
Clayton (Missouri),
Granite City, or
Brentwood (Missouri). You can also change your destination to
Canal Winchester,
Gahanna,
Grove City,
Hilliard,
Obetz,
Pickerington,
Reynoldsburg,
Dublin, or
New Albany (Ohio).