Top 7 trips from San Diego to San Luis Obispo

Explore alternate routes from San Diego to San Luis Obispo, or you can get reverse directions from San Luis Obispo to San Diego. Don't forget to factor in the weather. You can check the road conditions from San Diego to San Luis Obispo. Check out other stops like Los Angeles, Santa Monica, Santa Barbara, Venice Beach, Manhattan Beach, Malibu, Laguna Beach, Hermosa Beach, Solvang, Redondo Beach, or Newport Beach. Try starting your trip from Chula Vista, La Mesa, National City, Santee, Lemon Grove, La Jolla, Coronado (California), Imperial Beach, or Spring Valley (California). You can also change your destination to Avila Beach, Grover Beach, Oceano, Shell Beach, Los Osos (California), Arroyo Grande, Morro Bay, Pismo Beach (California), or Baywood-Los Osos.