Top 7 trips from Nashville to St. Louis

Nashville to St. Louis
starting from Nashville
1 hour → Hopkinsville
1.5 hours → Paducah
2 hours → Shawnee National Forest
1 hour → Burton's Cafe
2 hours → Nashville
60 minutes → St. Louis
6 hours of driving
Nashville to St. Louis via Metropolis
starting from Nashville
3 hours → Clarksville
1.5 hours → Metropolis
2 hours → Nashville
60 minutes → St. Louis


5.5 hours of driving
Nashville to St. Louis via Cape Girardeau
starting from Nashville
1 hour → Hopkinsville
53 minutes → Grand Rivers
2 hours → Cape Girardeau
2 hours → St. Louis


6 hours of driving
Nashville to St. Louis via Metropolis
starting from Nashville
1 hour → Oak Grove
1.5 hours → Metropolis
2 hours → Carlyle
1 hour → St. Louis


6 hours of driving
Nashville to St. Louis via Cape Girardeau
starting from Nashville
3 hours → Clarksville
1 hour → Hopkinsville
53 minutes → Grand Rivers
2 hours → Cape Girardeau
2 hours → St. Louis

6 hours of driving
Nashville to St. Louis via Hodgenville
starting from Nashville
2.5 hours → Hodgenville
2 hours → Evansville
2 hours → Nashville
60 minutes → St. Louis


7.5 hours of driving
Nashville to St. Louis via Lookout Mountain
starting from Nashville
2.5 hours → Lookout Mountain
3 hours → Clarksville
2 hours → Shawnee National Forest
1.5 hours → Mount Vernon
1 hour → St. Louis

10 hours of driving

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Explore alternate routes from Nashville to St. Louis, or you can get reverse directions from St. Louis to Nashville. Don't forget to factor in the weather. You can check the road conditions from Nashville to St. Louis. Check out other stops like Metropolis, Cape Girardeau, Hodgenville (Kentucky), or Lookout Mountain. Try starting your trip from Goodlettsville, Brentwood (Tennessee), Belle Meade, or Antioch. You can also change your destination to Cahokia, Caseyville, East Saint Louis, Pontoon Beach, Florissant, Hazelwood, Clayton (Missouri), Granite City, or Brentwood (Missouri).