Top 6 trips from Memphis to St. Louis

Memphis to St. Louis
starting from Memphis
52 minutes → Keiser
1 hour → Hayti
2 hours → Sikeston
1 hour → Cape Girardeau
49 minutes → Sainte Genevieve
1 hour → St. Louis


5.5 hours of driving
West Memphis to Florissant
starting from West Memphis
1 hour → Blytheville
50 minutes → Marston
1 hour → Cape Girardeau
40 minutes → Sedgewickville
49 minutes → Sainte Genevieve
1 hour → St. Louis
5 minutes → Florissant
6 hours of driving
West Memphis to East Saint Louis
starting from West Memphis
1 hour → Blytheville
50 minutes → Marston
1 hour → Cape Girardeau
40 minutes → Sedgewickville
49 minutes → Sainte Genevieve
55 minutes → Sylvan Springs
19 minutes → East Saint Louis
6 hours of driving
Memphis to St. Louis via Sikeston
starting from Memphis
52 minutes → Keiser
2 hours → Sikeston
2.5 hours → St. Louis




5 hours of driving
Memphis to St. Louis via Dyersburg
starting from Memphis
1.5 hours → Dyersburg
1 hour → Cape Girardeau
49 minutes → Sainte Genevieve
1 hour → St. Louis



5.5 hours of driving
Memphis to St. Louis via Dyersburg
starting from Memphis
1.5 hours → Dyersburg
1 hour → Cape Girardeau
49 minutes → Sainte Genevieve
42 minutes → Pevely
31 minutes → St. Louis


5.5 hours of driving

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Explore alternate routes from Memphis to St. Louis, or you can get reverse directions from St. Louis to Memphis. Don't forget to factor in the weather. You can check the road conditions from Memphis to St. Louis. Check out other stops like Sikeston or Dyersburg. Try starting your trip from West Memphis, Southaven (Mississippi), or Marion (Arkansas). You can also change your destination to Cahokia, Caseyville, East Saint Louis, Pontoon Beach, Florissant, Hazelwood, Clayton (Missouri), Granite City, or Brentwood (Missouri).