Top 9 trips from Los Angeles to San Luis Obispo

Explore alternate routes from Los Angeles to San Luis Obispo, or you can get reverse directions from San Luis Obispo to Los Angeles. Don't forget to factor in the weather. You can check the road conditions from Los Angeles to San Luis Obispo. Check out other stops like Los Olivos, Ojai, Bakersfield, or Upland. Try starting your trip from Glendale, Alhambra (California), Bell Gardens, Inglewood, Montebello, Monterey Park, Pasadena, Hollywood, or East Los Angeles. You can also change your destination to Avila Beach or Santa Margarita (California).