Top 9 trips from Lexington to St. Louis

Lexington to St. Louis
starting from Lexington
43 minutes → Frankfort
57 minutes → Louisville
1.5 hours → Jasper
1 hour → Evansville
2 hours → Nashville
60 minutes → St. Louis









7.5 hours of driving
Lexington to East Saint Louis
starting from Lexington
1.5 hours → Louisville
1 hour → Dale
48 minutes → Evansville
44 minutes → Grayville
1 hour → Mount Vernon
49 minutes → Carlyle
1 hour → East Saint Louis








7 hours of driving
Lexington to St. Louis via Bardstown
starting from Lexington
12 minutes → Keeneland Race Track
16 minutes → Versailles
21 minutes → Four Roses Distillery
48 minutes → Bardstown
45 minutes → Louisville
1.5 hours → Jasper
1 hour → Evansville
44 minutes → Grayville
1 hour → Mount Vernon
1 hour → St. Louis




8 hours of driving
Lexington to St. Louis via Mount Vernon
starting from Lexington
43 minutes → Frankfort
57 minutes → Louisville
44 minutes → Leavenworth
49 minutes → Jasper
1 hour → Evansville
44 minutes → Grayville
46 minutes → McLeansboro
39 minutes → Mount Vernon
36 minutes → Nashville
42 minutes → La Quinta Inn and Suites O'Fallon/Mascoutah
35 minutes → St. Louis



8.5 hours of driving
Lexington to East Saint Louis via Mount Vernon
starting from Lexington
43 minutes → Frankfort
57 minutes → Louisville
44 minutes → Leavenworth
49 minutes → Jasper
1 hour → Evansville
44 minutes → Grayville
46 minutes → McLeansboro
39 minutes → Mount Vernon
39 minutes → Best Western U. S. Inn
42 minutes → Scott Air Force Base FamCamp
32 minutes → East Saint Louis



8.5 hours of driving
Lexington to St. Louis via Bowling Green
starting from Lexington
43 minutes → Frankfort
1 hour → Bardstown
27 minutes → Elizabethtown
54 minutes → Mammoth Cave National Park
38 minutes → Bowling Green
1.5 hours → the glass factory
49 minutes → Evansville
1.5 hours → Mount Vernon
36 minutes → Nashville
48 minutes → Shiloh
26 minutes → St. Louis



9.5 hours of driving
Lexington to St. Louis via Indianapolis
starting from Lexington
43 minutes → Frankfort
57 minutes → Louisville
37 minutes → Scottsburg
37 minutes → North Vernon
40 minutes → Taylorsville
50 minutes → Indianapolis Zoo
5 minutes → Indianapolis
46 minutes → Cloverdale
39 minutes → Terre Haute
41 minutes → Casey
49 minutes → Effingham
53 minutes → Greenville
45 minutes → Collinsville
23 minutes → St. Louis
9.5 hours of driving
Lexington to St. Louis via Paducah
starting from Lexington
38 minutes → Lawrenceburg
43 minutes → Bardstown
57 minutes → Western Kentucky Parkway
1.5 hours → Central City
47 minutes → Dawson Springs
52 minutes → Grand Rivers
30 minutes → Paducah
44 minutes → Shawnee National Forest
48 minutes → West Frankfort
44 minutes → Mount Vernon
36 minutes → Nashville
1 hour → Granite City
22 minutes → St. Louis

10 hours of driving
Lexington to St. Louis via Clarksville
starting from Lexington
43 minutes → Frankfort
1 hour → Bardstown
1.5 hours → Mammoth Cave National Park
38 minutes → Bowling Green
40 minutes → Russellville
47 minutes → Clarksville
40 minutes → Hopkinsville
53 minutes → Grand Rivers
1.5 hours → West Frankfort
44 minutes → Mount Vernon
36 minutes → Nashville
48 minutes → O'Fallon
22 minutes → St. Louis

10.5 hours of driving

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Explore alternate routes from Lexington to St. Louis, or you can get reverse directions from St. Louis to Lexington. Don't forget to factor in the weather. You can check the road conditions from Lexington to St. Louis. Check out other stops like Louisville, Indianapolis, Bardstown, Paducah, Bowling Green, Terre Haute, Clarksville, Mount Vernon (Illinois), Grand Rivers, or Evansville. You can also change your destination to East Saint Louis, Clayton (Missouri), Brentwood (Missouri), Cahokia, Caseyville, Fairmont City, Columbia (Illinois), Richmond Heights, or Webster Groves (Missouri).