Top 9 trips from Indianapolis to St. Louis

Indianapolis to St. Louis
starting from Indianapolis
28 minutes → Gray Brothers Cafeteria
40 minutes → Greencastle
1.5 hours → Terre Haute
1 hour → Greenup
50 minutes → Altamont
2 hours → Greenville
54 minutes → St. Louis
5.5 hours of driving
Indianapolis to St. Louis via Robinson
starting from Indianapolis
2 hours → Robinson
2 hours → Greenville
54 minutes → St. Louis




5 hours of driving
Indianapolis to St. Louis via Mount Vernon
starting from Indianapolis
1.5 hours → Terre Haute
2.5 hours → Mount Vernon
1 hour → St. Louis




5 hours of driving
Indianapolis to St. Louis via Robinson
starting from Indianapolis
2 hours → Robinson
2 hours → Greenville
50 minutes → Shiloh
26 minutes → St. Louis



5 hours of driving
Indianapolis to St. Louis via Springfield
starting from Indianapolis
1 hour → Waynetown
1.5 hours → Urbana
1.5 hours → Springfield
1.5 hours → St. Louis



5.5 hours of driving
Indianapolis to St. Louis via Springfield
starting from Indianapolis
56 minutes → Crawfordsville
1.5 hours → Rantoul
1.5 hours → Springfield
1.5 hours → St. Louis



6 hours of driving
Indianapolis to St. Louis via Jasper
starting from Indianapolis
2.5 hours → Jasper
1.5 hours → Fairfield
1 hour → Nashville
60 minutes → St. Louis



6.5 hours of driving
Indianapolis to St. Louis via Evansville
starting from Indianapolis
1 hour → Bloomington
2 hours → Evansville
1 hour → Nashville
60 minutes → St. Louis



6.5 hours of driving
Indianapolis to St. Louis via Louisville
starting from Indianapolis
2 hours → Louisville
2 hours → New Harmony
1 hour → Nashville
60 minutes → St. Louis



6.5 hours of driving

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Explore alternate routes from Indianapolis to St. Louis, or you can get reverse directions from St. Louis to Indianapolis. Don't forget to factor in the weather. You can check the road conditions from Indianapolis to St. Louis. Check out other stops like Robinson, Mount Vernon (Illinois), Springfield (Illinois), Jasper (Indiana), Evansville, or Louisville. Try starting your trip from Greenwood, Beech Grove, Lawrence (Indiana), or Speedway (Indiana). You can also change your destination to Cahokia, Caseyville, East Saint Louis, Pontoon Beach, Florissant, Hazelwood, Clayton (Missouri), Granite City, or Brentwood (Missouri).