Top 6 trips from Des Moines to Chicago

Des Moines to Chicago
starting from Des Moines
1.5 hours → Brooklyn
1 hour → University of Iowa
1 hour → Moline
1 hour → Rock Falls
1 hour → Sycamore
1.5 hours → Chicago










7 hours of driving
Ankeny to Chicago
starting from Ankeny
1.5 hours → Brooklyn
1 hour → University of Iowa
1 hour → Davenport
1.5 hours → Dixon
1.5 hours → Naperville
37 minutes → Chicago










7 hours of driving
Clive to Chicago
starting from Clive
1.5 hours → Brooklyn
1 hour → University of Iowa
1 hour → Davenport
2 hours → Oglesby
1.5 hours → Orland Park
41 minutes → Chicago










7.5 hours of driving
Ankeny to Chicago via Iowa City
starting from Ankeny
54 minutes → Grinnell
57 minutes → Williamsburg
35 minutes → University of Iowa
5 minutes → Iowa City
1 hour → Davenport
1 hour → Rock Falls
1 hour → DeKalb
1 hour → Gene's & Jude's
23 minutes → Chicago






7 hours of driving
Des Moines to Chicago via Dyersville
starting from Des Moines
38 minutes → Ames
55 minutes → Iowa Falls
2.5 hours → Dyersville
2.5 hours → South Beloit
1 hour → The Vine - Martini & Wine Bar
55 minutes → Chicago









8 hours of driving
Ankeny to Chicago via Dyersville
starting from Ankeny
38 minutes → Ames
47 minutes → Webster City
41 minutes → Iowa Falls
40 minutes → Grundy Center
43 minutes → Evansdale
35 minutes → Oelwein
39 minutes → Manchester
29 minutes → Dyersville
35 minutes → Dubuque
52 minutes → Stockton
1 hour → Loves Park
41 minutes → Hampshire
35 minutes → Geneva
47 minutes → Bucktown
9 minutes → Chicago
10 hours of driving

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Explore alternate routes from Des Moines to Chicago, or you can get reverse directions from Chicago to Des Moines. Don't forget to factor in the weather. You can check the road conditions from Des Moines to Chicago. Check out other stops like Madison (Wisconsin), Bloomington (Illinois), Iowa City, Prairie du Sac, Davenport (Iowa), Brooklyn, Nauvoo, Dyersville, Galena, Bloomfield (Iowa), or Dyersville. Try starting your trip from West Des Moines, Ankeny, Clive, Johnston, Urbandale, Altoona (Iowa), Pleasant Hill (Iowa), or Norwalk (Iowa). You can also change your destination to Oak Park (Illinois), Elmhurst, Berwyn (Illinois), or Cicero (Illinois).