Top 6 trips from Cincinnati to St. Louis

Cincinnati to St. Louis
starting from Cincinnati
25 minutes → Creation Museum
2 hours → Indianapolis
2 hours → Terre Haute
1.5 hours → Altamont
1 hour → Old 66
53 minutes → St. Louis


7 hours of driving
Cincinnati to St. Louis via Louisville
starting from Cincinnati
2 hours → Louisville
2 hours → Evansville
1.5 hours → Mount Vernon
1 hour → St. Louis



6.5 hours of driving
Cincinnati to St. Louis via Louisville
starting from Cincinnati
2 hours → Louisville
2 hours → Evansville
48 minutes → Grayville
1.5 hours → Nashville
60 minutes → St. Louis


7 hours of driving
Cincinnati to St. Louis via New Harmony
starting from Cincinnati
46 minutes → Warsaw
1.5 hours → Corydon
2 hours → New Harmony
1.5 hours → Nashville
60 minutes → St. Louis


7 hours of driving
Cincinnati to St. Louis via Terre Haute
starting from Cincinnati
25 minutes → Dry Ridge
2 hours → Waverly Hills Sanatorium
1.5 hours → Jasper
2 hours → Evansville
2 hours → Terre Haute
1.5 hours → Nashville
60 minutes → St. Louis
11 hours of driving
Cincinnati to St. Louis via Terre Haute
starting from Cincinnati
2 hours → Louisville
2 hours → Terre Haute
1.5 hours → Jasper
2 hours → Evansville
1.5 hours → Nashville
60 minutes → St. Louis

11 hours of driving

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Explore alternate routes from Cincinnati to St. Louis, or you can get reverse directions from St. Louis to Cincinnati. Don't forget to factor in the weather. You can check the road conditions from Cincinnati to St. Louis. Check out other stops like Louisville, New Harmony, or Terre Haute (Indiana). Try starting your trip from Erlanger, Fort Mitchell, Fort Wright, Richwood, Blue Ash, Sharonville, Wilder, Covington (Kentucky), or Hebron (Kentucky). You can also change your destination to Collinsville (Illinois), Cahokia, Caseyville, East Saint Louis, Edwardsville, Fairview Heights, Clayton (Missouri), Granite City, or Brentwood (Missouri).